storing my drum sounds and samples

[The Whole Sandwich]

should I keep samples and drum sounds in a folder that is easy to access?

In order words, does LMMS slow down if it has to go into a folder that is in a subfolder?

[musikbear]

does LMMS slow down if it has to go into a folder that is in a subfolder?

No. It is recommended to use a subfolder structure in Samples
\Documents\lmms\samples\ is also the correct folder for all your VST-instruments